Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae
A key missing enzyme in the plant Panax ginseng Rg2 and Re2 ginsenoside biosynthesis pathway is identified, and its expression is engineered in yeast for high-level production.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03740-y |
| _version_ | 1818505243054309376 |
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| author | Chaojing Li Xing Yan Zhenzhen Xu Yan Wang Xiao Shen Lei Zhang Zhihua Zhou Pingping Wang |
| author_facet | Chaojing Li Xing Yan Zhenzhen Xu Yan Wang Xiao Shen Lei Zhang Zhihua Zhou Pingping Wang |
| author_sort | Chaojing Li |
| collection | DOAJ |
| description | A key missing enzyme in the plant Panax ginseng Rg2 and Re2 ginsenoside biosynthesis pathway is identified, and its expression is engineered in yeast for high-level production. |
| first_indexed | 2024-12-10T21:48:03Z |
| format | Article |
| id | doaj.art-f0e0e887012a4f3a98970c186160ae3a |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-10T21:48:03Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-f0e0e887012a4f3a98970c186160ae3a2022-12-22T01:32:19ZengNature PortfolioCommunications Biology2399-36422022-08-01511910.1038/s42003-022-03740-yPathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiaeChaojing Li0Xing Yan1Zhenzhen Xu2Yan Wang3Xiao Shen4Lei Zhang5Zhihua Zhou6Pingping Wang7CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of SciencesCAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of SciencesCAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of SciencesCAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of SciencesCAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of SciencesLogic Informatics Co., Ltd.CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of SciencesCAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of SciencesA key missing enzyme in the plant Panax ginseng Rg2 and Re2 ginsenoside biosynthesis pathway is identified, and its expression is engineered in yeast for high-level production.https://doi.org/10.1038/s42003-022-03740-y |
| spellingShingle | Chaojing Li Xing Yan Zhenzhen Xu Yan Wang Xiao Shen Lei Zhang Zhihua Zhou Pingping Wang Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae Communications Biology |
| title | Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae |
| title_full | Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae |
| title_fullStr | Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae |
| title_full_unstemmed | Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae |
| title_short | Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae |
| title_sort | pathway elucidation of bioactive rhamnosylated ginsenosides in panax ginseng and their de novo high level production by engineered saccharomyces cerevisiae |
| url | https://doi.org/10.1038/s42003-022-03740-y |
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