Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.

Current influenza vaccines do not elicit broadly protective immune responses against multiple strains. New strategies to focus the humoral immune response to conserved regions on influenza antigens are therefore required for recognition by broadly neutralizing antibodies. It has been suggested that...

Full description

Bibliographic Details
Main Authors: Alexander A Cohen, Zhi Yang, Priyanthi N P Gnanapragasam, Susan Ou, Kim-Marie A Dam, Haoqing Wang, Pamela J Bjorkman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0247963