Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
Current influenza vaccines do not elicit broadly protective immune responses against multiple strains. New strategies to focus the humoral immune response to conserved regions on influenza antigens are therefore required for recognition by broadly neutralizing antibodies. It has been suggested that...
Main Authors: | Alexander A Cohen, Zhi Yang, Priyanthi N P Gnanapragasam, Susan Ou, Kim-Marie A Dam, Haoqing Wang, Pamela J Bjorkman |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0247963 |
Similar Items
-
A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice
by: Susan Thrane, et al.
Published: (2020-07-01) -
Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens
by: Uddipan Kar, et al.
Published: (2022-05-01) -
Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate
by: Mark S Ladinsky, et al.
Published: (2020-07-01) -
Recombinant trimeric HA protein immunogenicity of H5N1 avian influenza viruses and their combined use with inactivated or adenovirus vaccines.
by: Shih-Chang Lin, et al.
Published: (2011-01-01) -
HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design
by: Kim-Marie A. Dam, et al.
Published: (2022-10-01)