C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum

C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum

Abstract Background Conditional ablation of the Smarca5 gene in mice severely impairs the postnatal growth of the cerebellum and causes an ataxic phenotype. Comparative gene expression studies indicated that complement-related proteins were upregulated in the cerebellum of Smarca5 mutant mice. Compl...

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Bibliographic Details
Main Authors: Kevin G. Young, Keqin Yan, David J. Picketts
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Bergmann glia
C3aR1
C3 complement
Macrophage
Microglia
MerTK
Online Access:http://link.springer.com/article/10.1186/s12974-019-1530-4

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http://link.springer.com/article/10.1186/s12974-019-1530-4

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