Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome

Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome

Lysosomal dysfunction has been proposed as one of the most important pathogenic molecular mechanisms in Parkinson disease (PD). The most significant evidence lies in the <i>GBA</i> gene, which encodes for the lysosomal enzyme β-glucocerebrosidase (β-GCase), considered the main genetic ri...

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Bibliographic Details
Main Authors: Clara Ruz, Francisco J. Barrero, Javier Pelegrina, Sara Bandrés-Ciga, Francisco Vives, Raquel Duran
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
lysosomal dysfunction
β-glucocerebrosidase
PSAP
Cathepsin D
Online Access:https://www.mdpi.com/1422-0067/23/19/12004

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