High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy

High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy

Although the eukaryotic elongation factor eEF1A1 plays a role in various tumours, there is little information on its prognosis/therapeutic value in prostate carcinoma. In high-grade and castration-resistant prostate carcinoma (CRPC), the identification of novel therapeutic markers/targets remains a...

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Bibliographic Details
Main Authors: Alessandra Bosutti, Barbara Dapas, Gabriele Grassi, Rossana Bussani, Fabrizio Zanconati, Fabiola Giudici, Cristina Bottin, Nicola Pavan, Carlo Trombetta, Bruna Scaggiante
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
castration-resistant prostate cancer
cytotoxicity
confocal microscopy
eukaryotic elongation factor 1A1
GT75 aptamer
immunohistochemistry
Online Access:https://www.mdpi.com/1422-0067/23/8/4143

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https://www.mdpi.com/1422-0067/23/8/4143

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