Analysis of Intrinsic Breast Cancer Subtypes: The Clinical Utility of Epigenetic Biomarkers and <i>TP53</i> Mutation Status in Triple-Negative Cases

Analysis of Intrinsic Breast Cancer Subtypes: The Clinical Utility of Epigenetic Biomarkers and <i>TP53</i> Mutation Status in Triple-Negative Cases

This study aimed at analyzing the DNA methylation pattern and <i>TP53</i> mutation status of intrinsic breast cancer (BC) subtypes for improved characterization and survival prediction. DNA methylation of 17 genes was tested by methylation-specific PCR in 116 non-familial <i>BRCA&l...

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Bibliographic Details
Main Authors: Ieva Sadzeviciene, Kristina Snipaitiene, Asta Scesnaite-Jerdiakova, Kristina Daniunaite, Rasa Sabaliauskaite, Aida Laurinaviciene, Monika Drobniene, Valerijus Ostapenko, Sonata Jarmalaite
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
triple-negative breast cancer
DNA hypermethylation
<i>TP53</i>
<i>FILIP1L</i>
<i>MT1E</i>
Online Access:https://www.mdpi.com/1422-0067/23/23/15429

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https://www.mdpi.com/1422-0067/23/23/15429

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