Collagen and Discoidin Domain Receptor 1 Partnership: A Multifaceted Role in the Regulation of Breast Carcinoma Cell Phenotype

Collagen and Discoidin Domain Receptor 1 Partnership: A Multifaceted Role in the Regulation of Breast Carcinoma Cell Phenotype

Type I collagen, the major components of breast interstitial stroma, is able to regulate breast carcinoma cell behavior. Discoidin domain receptor 1 (DDR1) is a type I collagen receptor playing a key role in this process. In fact, collagen/DDR1 axis is able to trigger the downregulation of cell prol...

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Bibliographic Details
Main Authors: Charles Saby, Erik Maquoi, Frédéric Saltel, Hamid Morjani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
type I collagen
aging
DDRs
MT1-MMP
apoptosis
linear invadosomes
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.808625/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.808625/full

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