In-Depth Characterization of a Re-Engineered Cholera Toxin Manufacturing Process Using Growth-Decoupled Production in <i>Escherichia coli</i>

In-Depth Characterization of a Re-Engineered Cholera Toxin Manufacturing Process Using Growth-Decoupled Production in <i>Escherichia coli</i>

Non-toxic derivatives of the cholera toxin are extensively used in neuroscience, as neuronal tracers to reveal the location of cells in the central nervous system. They are, also, being developed as vaccine components and drug-delivery vehicles. Production of cholera-toxin derivatives is often non-r...

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Bibliographic Details
Main Authors: Natalia Danielewicz, Wenyue Dai, Francesca Rosato, Michael E. Webb, Gerald Striedner, Winfried Römer, W. Bruce Turnbull, Juergen Mairhofer
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Toxins
Subjects:
cholera toxin
holotoxin-like chimaera
neuronal tracer
T2SS machinery
GM1 receptor
retrograde transport
Online Access:https://www.mdpi.com/2072-6651/14/6/396

Internet

https://www.mdpi.com/2072-6651/14/6/396

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