Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases

Abstract Trk-fused gene (TFG) mutations have been identified in patients with several neurodegenerative diseases. In this study, we attempted to clarify the effects of TFG deletions in motor neurons and in muscle fibers, using tissue-specific TFG knockout (vMNTFG KO and MUSTFG KO) mice. vMNTFG KO, g...

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Bibliographic Details
Main Authors: Takeshi Yamamotoya, Shun Hasei, Yasuyuki Akasaka, Yukino Ohata, Yusuke Nakatsu, Machi Kanna, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Akifumi Kushiyama, Hidemi Misawa, Tomoichiro Asano
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05884-7

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https://doi.org/10.1038/s41598-022-05884-7

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