Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR

Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR

Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely used to treat asthma disorders, while CysLT2R is a po...

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Bibliographic Details
Main Authors: Arman A. Sadybekov, Rebecca L. Brouillette, Egor Marin, Anastasiia V. Sadybekov, Aleksandra Luginina, Anastasiia Gusach, Alexey Mishin, Élie Besserer-Offroy, Jean-Michel Longpré, Valentin Borshchevskiy, Vadim Cherezov, Philippe Sarret, Vsevolod Katritch
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
structure-based lead discovery
virtual ligand screening
GPCR
cysteinyl leukotriene
CysLT receptors
asthma
Online Access:https://www.mdpi.com/2218-273X/10/12/1634

Internet

https://www.mdpi.com/2218-273X/10/12/1634

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