Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR

Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely used to treat asthma disorders, while CysLT2R is a po...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Arman A. Sadybekov, Rebecca L. Brouillette, Egor Marin, Anastasiia V. Sadybekov, Aleksandra Luginina, Anastasiia Gusach, Alexey Mishin, Élie Besserer-Offroy, Jean-Michel Longpré, Valentin Borshchevskiy, Vadim Cherezov, Philippe Sarret, Vsevolod Katritch
التنسيق:	مقال
اللغة:	English
منشور في:	MDPI AG 2020-12-01
سلاسل:	Biomolecules
الموضوعات:	structure-based lead discovery virtual ligand screening GPCR cysteinyl leukotriene CysLT receptors asthma
الوصول للمادة أونلاين:	https://www.mdpi.com/2218-273X/10/12/1634

الانترنت

https://www.mdpi.com/2218-273X/10/12/1634

Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR

الانترنت

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