Anakinra Activates Superoxide Dismutase 2 to Mitigate Inflammasome Activity

Anakinra Activates Superoxide Dismutase 2 to Mitigate Inflammasome Activity

Inflammasomes are powerful cytosolic sensors of environmental stressors and are critical for triggering interleukin-1 (IL-1)-mediated inflammatory responses. However, dysregulation of inflammasome activation may lead to pathological conditions, and the identification of negative regulators for thera...

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Bibliographic Details
Main Authors: Marilena Pariano, Stefania Pieroni, Antonella De Luca, Rossana G. Iannitti, Monica Borghi, Matteo Puccetti, Stefano Giovagnoli, Giorgia Renga, Fiorella D’Onofrio, Marina M. Bellet, Claudia Stincardini, Maria Agnese Della-Fazia, Giuseppe Servillo, Frank L. van de Veerdonk, Claudio Costantini, Luigina Romani
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
NLRP3 inflammasome
anakinra
superoxide dismutase 2
oxidative stress
cystic fibrosis
chronic granulomatous disease
Online Access:https://www.mdpi.com/1422-0067/22/12/6531

Internet

https://www.mdpi.com/1422-0067/22/12/6531

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