Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver

Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver

Here, we studied the effects of cytochrome P450 (CYP)3A deficiency on the mRNA expression of genes encoding regulators of hepatic cholesterol levels using Cyp3a-knockout (Cyp3a−/−) mice. The mRNA expression levels of genes encoding enzymes involved in cholesterol biosynthesis in the livers of Cyp3a−...

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Bibliographic Details
Main Authors: Mari Hashimoto, Kaoru Kobayashi, Mio Watanabe, Yasuhiro Kazuki, Shoko Takehara, Asumi Inaba, Shin-ichiro Nitta, Naoto Senda, Mitsuo Oshimura, Kan Chiba
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Journal of Lipid Research
Subjects:
25-hydroxy-cholesterol
HMG-CoA synthase 1
squalene epoxidase
sterol regulatory element-binding protein-2
cytochrome P450 3A
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375234

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http://www.sciencedirect.com/science/article/pii/S0022227520375234

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