Bridging Basic and Clinical Research in Early Life Adversity, DNA Methylation, and Major Depressive Disorder

Early life adversity (ELA)- including childhood physical, emotional, and sexual abuse, as well as childhood neglect- is an important predictive factor for negative psychopathology, including Major Depressive Disorder (MDD). ELA can epigenetically regulate key emotional and behavioral systems in ways...

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Bibliographic Details
Main Authors: Amanda Brown, Laura M. Fiori, Gustavo Turecki
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00229/full