Studies on the Q175 knock-in model of Huntington’s disease using functional imaging in awake mice: evidence of olfactory dysfunction

Studies on the Q175 knock-in model of Huntington’s disease using functional imaging in awake mice: evidence of olfactory dysfunction

BOLD imaging in awake mice was used to identify differences in brain activity between wild-type, HETzQ175 and HOMzQ175 genotypes in response to the odor of almond. The study was designed to see how alterations in the huntingtin gene in a mouse model of Huntington's disease would affect the perc...

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Bibliographic Details
Main Authors: Craig F Ferris, Praveen eKulkarni, Steven eToddes, Jason Richard Yee, William eKenkel, Mark eNedelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Neurology
Subjects:
Feeding Behavior
Neural Pathways
reward processing
BOLD fMRI
huntingtin-associated protein 1
awake animal imaging
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00094/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00094/full

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