A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis

A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis

Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression. Single nucleotide polymorphisms (SNPs) in AOE and...

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Bibliographic Details
Main Authors: Jeffrey M. Chambliss, Maria Ansar, John P. Kelley, Heidi Spratt, Roberto P. Garofalo, Antonella Casola
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
pneumovirus
lung disease
bronchiolitis
catalase
polymorphism
Online Access:https://www.mdpi.com/1999-4915/12/1/57

Internet

https://www.mdpi.com/1999-4915/12/1/57

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