Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Abstract Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated ubiquitylation. Unlike sporadic clear‐cell renal carcinomas, VHL mutation is rarely observed in hepat...

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Bibliographic Details
Main Authors: Xinxin Liu, Xiaoli Zhang, Zhiqiang Peng, Chunnan Li, Ze Wang, Chanjuan Wang, Zhikang Deng, Bo Wu, Yu Cui, Zhanxin Wang, Chun‐Ping Cui, Min Zheng, Lingqiang Zhang
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Advanced Science
Subjects:
deubiquitylase
hepatocellular carcinoma metastasis
hypoxia inducible factor
OTUD6B
von Hippel–Lindau
Online Access:https://doi.org/10.1002/advs.201902040

Internet

https://doi.org/10.1002/advs.201902040

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