Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles

Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles

Efficient degradation of phagocytic cargo in lysosomes is crucial to maintain cellular homeostasis and defending cells against pathogens. However, the mechanisms underlying the degradation and recycling of macromolecular cargo within the phagolysosome remain incompletely understood. We previously re...

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Bibliographic Details
Main Authors: Rebecca Holzapfel, Agata Prell, Fabian Schumacher, Veronika Perschin, José Pedro Friedmann Angeli, Burkhard Kleuser, Christian Stigloher, Gholamreza Fazeli
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:European Journal of Cell Biology
Subjects:
Phagolysosome resolution
Cell corpse clearance
Lysosome
Sphingolipidome
Hexosylceramides
Glucosyl ceramidases
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933524000281

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http://www.sciencedirect.com/science/article/pii/S0171933524000281

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