Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

Summary: Malaria eradication requires the development of new drugs to combat drug-resistant parasites. We identified bisbenzylisoquinoline alkaloids isolated from Cocculus hirsutus that are active against Plasmodium falciparum blood stages. Synthesis of a library of 94 hemi-synthetic derivatives all...

Full description

Bibliographic Details
Main Authors: Flore Nardella, Irina Dobrescu, Haitham Hassan, Fabien Rodrigues, Sabine Thiberge, Liliana Mancio-Silva, Ambre Tafit, Corinne Jallet, Véronique Cadet-Daniel, Stéphane Goussin, Audrey Lorthiois, Yoann Menon, Nicolas Molinier, Dany Pechalrieu, Christophe Long, François Sautel, Mariette Matondo, Magalie Duchateau, Guillaume Médard, Benoit Witkowski, Artur Scherf, Ludovic Halby, Paola B. Arimondo
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Multi-drug resistant organisms
Natural product chemistry
Applied microbiology
Microbiology parasite
Clinical microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223000172

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223000172

Similar Items