In-cell Western assay to quantify infection with pathogenic orthohantavirus Puumala virus in replication kinetics and antiviral drug testing

Hemorrhagic fever with renal syndrome (HFRS) represents a serious zoonotic disease caused by orthohantaviruses in Eurasia. A specific antiviral therapy is not available. HFRS is characterized by acute kidney injury (AKI) with often massive proteinuria. Infection of kidney cells may contribute to the...

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Bibliographic Details
Main Authors: Christian Nusshag, Pamela Schreiber, Josephine Uhrig, Martin Zeier, Ellen Krautkrämer
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Virus Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170223001922