Sex difference in circulating PCSK9 and its clinical implications

Sex difference in circulating PCSK9 and its clinical implications

Proprotein convertase subtilisin kexin type 9 (PCSK9) is a proprotein convertase that increases plasma low-density lipoprotein cholesterol (LDL-C) levels by triggering the degradation of LDL receptors (LDLRs). Beyond the regulation of circulating LDL-C, PCSK9 also has direct atherosclerotic effects...

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Bibliographic Details
Main Authors: Fang Jia, Si-Fan Fei, De-Bing Tong, Cong Xue, Jian-Jun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
proprotein convertase subtilisin kexin type 9
sex difference
estrogen
coronary artery disease
PCSK9 inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.953845/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.953845/full

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