Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis

Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis

The relationship between the cluster of differentiation 226 (CD226)/T cell Ig and ITIM domain (TIGIT) immune checkpoint and primary biliary cholangitis (PBC) pathogenesis is unknown. Herein, PBC patients (n = 42) showed significantly higher proportions of peripheral CD8+ T and CD4+ T cells expressin...

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Bibliographic Details
Main Authors: Chuiwen Deng, Wenli Li, Yunyun Fei, Li Wang, Yingying Chen, Xiaofeng Zeng, Fengchun Zhang, Yongzhe Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
primary biliary cholangitis
CD226
TIGIT
immune checkpoint
pathogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01619/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01619/full

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