Phosphorylation of eIF2α mitigates endoplasmic reticulum stress and hepatocyte necroptosis in acute liver injury

Phosphorylation of eIF2α mitigates endoplasmic reticulum stress and hepatocyte necroptosis in acute liver injury

Introduction and objectives: Necroptosis and endoplasmic reticulum (ER) stress has been implicated in acute and chronic liver injury. Activated eukaryotic initiation factor 2 alpha (eIF2α) attenuates protein synthesis and relieves the load of protein folding in the ER. In this study, we aimed to ana...

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Bibliographic Details
Main Authors: Ren-Dong Tian, Yi-Qun Chen, Yi-Huai He, Yong-Jing Tang, Gui-Mei Chen, Fang-Wan Yang, Ying Li, Wen-Ge Huang, Huan Chen, Xia Liu, Shi-De Lin
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Annals of Hepatology
Subjects:
Eukaryotic initiation factor 2α
Endoplasmic reticulum stress
Necroptosis
Tumor necrosis factor receptor 1
Acute liver injury
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119322276

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http://www.sciencedirect.com/science/article/pii/S1665268119322276

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