Complement Factor D Is a Novel Biomarker and Putative Therapeutic Target in Cutaneous Squamous Cell Carcinoma

Complement Factor D Is a Novel Biomarker and Putative Therapeutic Target in Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (cSCC) is the most prevalent metastatic skin cancer. Previous studies have demonstrated the autocrine role of complement components in cSCC progression. We have investigated factor D (FD), the key enzyme of the alternative complement pathway, in the development of c...

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Bibliographic Details
Main Authors: Pegah Rahmati Nezhad, Pilvi Riihilä, Jaakko S. Knuutila, Kristina Viiklepp, Sirkku Peltonen, Markku Kallajoki, Seppo Meri, Liisa Nissinen, Veli-Matti Kähäri
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
complement
cutaneous squamous cell carcinoma
skin
progression
factor D
adipsin
Online Access:https://www.mdpi.com/2072-6694/14/2/305

Internet

https://www.mdpi.com/2072-6694/14/2/305

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