New lathyrane diterpenoid hybrids have anti-inflammatory activity through the NF-κB signaling pathway and autophagy

In our ongoing work on the identification of potent anti-inflammatory agents, we designed and synthesized three series of lathyrane diterpenoid hybrids in which the lathyrane diterpenoid skeleton was hybridized with other anti-inflammatory pharmacophores. Unexpectedly, lathyrane diterpenoid/3-hydrox...

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Bibliographic Details
Main Authors: Wang Wang, Liangliang Xiong, Yanli Wu, Yirong Zhou, Yutong Li, Mengzhu Zheng, Zhuorui Song, Dejuan Sun, Lixia Chen
Format: Article
Language:English
Published: Compuscript Ltd 2022-05-01
Series:Acta Materia Medica
Subjects:
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0008