In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons

In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons

Summary: Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to model human-specific phenotypes in an in vivo environ...

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Bibliographic Details
Main Authors: Ramsey Najm, Kelly A. Zalocusky, Misha Zilberter, Seo Yeon Yoon, Yanxia Hao, Nicole Koutsodendris, Maxine Nelson, Antara Rao, Alice Taubes, Emily A. Jones, Yadong Huang
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
Aβ
apoE4
chimeric disease modeling
excitatory neuron
human iPSC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309438

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http://www.sciencedirect.com/science/article/pii/S2211124720309438

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