PDE-5-Inhibited BMSCs Alleviate High Glucose-Induced Myocardial Fibrosis and Cardiomyocyte Apoptosis by Activating the cGMP/PKG Pathway

PDE-5-Inhibited BMSCs Alleviate High Glucose-Induced Myocardial Fibrosis and Cardiomyocyte Apoptosis by Activating the cGMP/PKG Pathway

Background: Phosphodiesterase-5 (PDE-5) inhibitors have been found to play an important cardio-protective role. This study aimed to clarify the inhibitory effects of PDE-5-silenced bone marrow mesenchymal stem cells (BMSCs) on high glucose-induced myocardial fibrosis and cardiomyocyte apoptosis. Met...

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Bibliographic Details
Main Authors: Qinghua Huang, Jiangbo Ma, Hui Wu, Jieru Zhou, Lei Jiang, Xianming Fei
Format: Article
Language:English
Published: IMR Press 2023-07-01
Series:Frontiers in Bioscience-Landmark
Subjects:
phosphodiesterase-5
bmscs
diabetic cardiomyopathy
cgmp/pkg pathway
myocardial fibrosis
cardiomyocytes apoptosis
Online Access:https://www.imrpress.com/journal/FBL/28/7/10.31083/j.fbl2807155

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https://www.imrpress.com/journal/FBL/28/7/10.31083/j.fbl2807155

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