CRISPR/Cas9-mediated Bag-1 knockout increased mesenchymal characteristics of MCF-7 cells via Akt hyperactivation-mediated actin cytoskeleton remodeling

CRISPR/Cas9-mediated Bag-1 knockout increased mesenchymal characteristics of MCF-7 cells via Akt hyperactivation-mediated actin cytoskeleton remodeling

Bag-1 protein is a crucial target in cancer to increase the survival and proliferation of cells. The Bag-1 expression is significantly upregulated in primary and metastatic cancer patients compared to normal breast tissue. Overexpression of Bag-1 decreases the efficiency of conventional chemotherape...

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Bibliographic Details
Main Authors: Pelin Ozfiliz Kilbas, Nisan Denizce Can, Tugba Kizilboga, Fikret Ezberci, Hamdi Levent Doganay, Elif Damla Arisan, Gizem Dinler Doganay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741009/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741009/?tool=EBI

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