α-Synuclein seeding activity in duodenum biopsies from Parkinson's disease patients.

α-Synuclein seeding activity in duodenum biopsies from Parkinson's disease patients.

Abnormal deposition of α-synuclein is a key feature and biomarker of Parkinson's disease. α-Synuclein aggregates can propagate themselves by a prion-like seeding-based mechanism within and between tissues and are hypothesized to move between the intestine and brain. α-Synuclein RT-QuIC seed amp...

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Bibliographic Details
Main Authors: Sarah Vascellari, Christina D Orrù, Bradley R Groveman, Sabiha Parveen, Giuseppe Fenu, Giada Pisano, Giuseppe Piga, Giulia Serra, Valentina Oppo, Daniela Murgia, Andrea Perra, Fabrizio Angius, Andrew G Hughson, Cathryn L Haigh, Aldo Manzin, Giovanni Cossu, Byron Caughey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011456

Internet

https://doi.org/10.1371/journal.ppat.1011456

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