APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1

APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1

ABSTRACT Humans encode proteins, called restriction factors, that inhibit replication of viruses such as HIV-1. The members of one family of antiviral proteins, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; shortened here to A3), act by deaminating cytidines to uridines...

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Bibliographic Details
Main Authors: Mollie M. McDonnell, Kate H. D. Crawford, Adam S. Dingens, Jesse D. Bloom, Michael Emerman
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
APOBEC3C
HIV-1
restriction factor
Vif
innate immunity
Online Access:https://journals.asm.org/doi/10.1128/mBio.00737-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00737-20

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