First Stereoselective Total Synthesis of Ciryneol C

First Stereoselective Total Synthesis of Ciryneol C

Abstract The acetylene derivative Ciryneol C was isolated from the roots of C. japonicum. The asymmetric total synthesis of Ciryneol C was achieved in seven steps, with Horner–Wittig olefination, regioselective epoxide opening, and Cadiot–Chodkiewicz coupling reactions being the key steps.

Bibliographic Details
Main Authors: Ambati Sharada, Lakshmi Srinivasa Rao Kundeti, Kallaganti V. S. Ramakrishna, Kommu Nagaiah
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2019-04-01
Series:SynOpen
Subjects:
acetylene
cadiot–chodkiewicz coupling
natural products
sharpless asymmetric epoxidation
total synthesis
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1611876

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1611876

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