Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency.

Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in cystic fibrosis or Shwachman-Diamond syndrome. In this study, a mouse model for isolated exocrine PI...

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Bibliographic Details
Main Authors: Stacie K Loftus, Jennifer L Cannons, Arturo Incao, Evgenia Pak, Amy Chen, Patricia M Zerfas, Mark A Bryant, Leslie G Biesecker, Pamela L Schwartzberg, William J Pavan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1231717?pdf=render