Abnormal processing of tau in the brain of aged TgCRND8 mice

Abnormal processing of tau in the brain of aged TgCRND8 mice

Amyloid plaques and neurofibrillary tangles are the main histopathological hallmarks of Alzheimer's disease (AD). In the neocortex and hippocampus of aged TgCRND8 mice, tau is hyperphosphorylated at different sites recognized by PHF-1, AT100, AT8 and CP13 antibodies. Phospho-SAPK/JNK levels wer...

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Bibliographic Details
Main Authors: Arianna Bellucci, Maria Cristina Rosi, Cristina Grossi, Anna Fiorentini, Ilaria Luccarini, Fiorella Casamenti
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Double APP transgenic mouse
TgCRND8
Hyperphosphorylated tau
SAPK/JNK
Nitrosative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001131

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http://www.sciencedirect.com/science/article/pii/S0969996107001131

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