Critical Role of Astrocytic Polyamine and GABA Metabolism in Epileptogenesis

Critical Role of Astrocytic Polyamine and GABA Metabolism in Epileptogenesis

Accumulating evidence indicate that astrocytes are essential players of the excitatory and inhibitory signaling during normal and epileptiform activity via uptake and release of gliotransmitters, ions, and other substances. Polyamines can be regarded as gliotransmitters since they are almost exclusi...

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Bibliographic Details
Main Authors: Zsolt Kovács, Serguei N. Skatchkov, Rüdiger W. Veh, Zsolt Szabó, Krisztina Németh, Pál T. Szabó, Julianna Kardos, László Héja
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
absence epilepsy
WAG/Rij rat model
APCHA/spermine synthase inhibitor
4-MCHA/spermidine synthase inhibitor
polyamines in the central nervous system
neurons
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.787319/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.787319/full

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