Immunotherapy with STING and TLR9 agonists promotes synergistic therapeutic efficacy with suppressed cancer-associated fibroblasts in colon carcinoma

Immunotherapy with STING and TLR9 agonists promotes synergistic therapeutic efficacy with suppressed cancer-associated fibroblasts in colon carcinoma

The innate immune sensing of nucleic acids using effective immunoadjuvants is critical for increasing protective immune responses against cancer. Stimulators of interferon genes (STING) and toll-like receptor 9 (TLR9) agonists are considered promising candidates in several preclinical tumor models w...

Full description

Bibliographic Details
Main Authors: Sare Hajiabadi, Soodeh Alidadi, Zohreh Montakhab Farahi, Mohammad M. Ghahramani Seno, Hamidreza Farzin, Alireza Haghparast
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
STING
TLR9
immunoadjuvants
CAFs
colon carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1258691/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1258691/full

Similar Items