What mechanisms are responsible for the reuptake of levodopa-derived dopamine in parkinsonian striatum?

Levodopa is the most effective medication for motor symptoms in Parkinson’s disease. However, various motor and non-motor complications are associated with levodopa treatment, resulting from altered levodopa-dopamine metabolism with disease progression and long-term use of the drug. The present revi...

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Bibliographic Details
Main Authors: Haruo Nishijima, Masahiko Tomiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00575/full