Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma

Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) commonly possesses chronical elevation of IRE1α-ASK1 signaling. Orphan nuclear receptor Nur77, a promising therapeutic target in various cancer types, is frequently silenced in HCC. In this study, we show that cryptomeridiol (Bkh126), a naturally occurring sesquiterpen...

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Bibliographic Details
Main Authors: Xudan Li, Quancheng Chen, Jie Liu, Shenjin Lai, Minda Zhang, Tidong Zhen, Hongyu Hu, Xiang Gao, Alice S. T. Wong, Jin-Zhang Zeng
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
sesquiterpenoid
drug target
orphan nuclear receptor Nur77
ER stress
mitochondrial membrane potential
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2073-4409/11/23/3870

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https://www.mdpi.com/2073-4409/11/23/3870

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