Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (EVD). While antiviral effects have...

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Bibliographic Details
Main Authors: Egor P. Tchesnokov, Joy Y. Feng, Danielle P. Porter, Matthias Götte
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Viruses
Subjects:
Ebola virus
respiratory syncytial virus
RNA polymerase
RdRp
remdesivir
GS-5734
delayed chain termination
Online Access:https://www.mdpi.com/1999-4915/11/4/326

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https://www.mdpi.com/1999-4915/11/4/326

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