H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

Regulatory T cells (Treg) are crucial immune modulators, yet the exact mechanism of thymic Treg development remains controversial. Here, we present the first direct evidence for H2-O, an MHC class II peptide editing molecular chaperon, on selection of thymic Tregs. We identified that lack of H2-O in...

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Bibliographic Details
Main Authors: Robin A. Welsh, Nianbin Song, Chan-Su Park, J. David Peske, Scheherazade Sadegh-Nasseri
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
immunology
class II antigen presentation
regulatory T cells
thymic selection
CD4 T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1304798/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1304798/full

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