Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

Summary: Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine receptor 2 (RyR2) control of neuronal h...

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Bibliographic Details
Main Authors: Jinjing Yao, Bo Sun, Adam Institoris, Xiaoqin Zhan, Wenting Guo, Zhenpeng Song, Yajing Liu, Florian Hiess, Andrew K.J. Boyce, Mingke Ni, Ruiwu Wang, Henk ter Keurs, Thomas G. Back, Michael Fill, Roger J. Thompson, Ray W. Turner, Grant R. Gordon, S.R. Wayne Chen
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
β-amyloid deposition
learning and memory
hippocampal CA1 pyramidal neurons
neuronal hyperactivity
neuronal excitability
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031158X

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http://www.sciencedirect.com/science/article/pii/S221112472031158X

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