Protocol for quantifying pyramidal neuron hyperexcitability in a mouse model of neurodevelopmental encephalopathy

Protocol for quantifying pyramidal neuron hyperexcitability in a mouse model of neurodevelopmental encephalopathy

Summary: Here, we present a protocol for quantifying pyramidal neuron hyperexcitability in a mouse model of STXBP1 neurodevelopmental encephalopathy (Stxbp1hap). We describe steps for preparing brain slices, positioning electrodes, and performing an excitability test to investigate microcircuit fail...

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Bibliographic Details
Main Authors: Altair Brito dos Santos, Silas Dalum Larsen, Carlos Daniel Gomez, Jakob Balslev Sørensen, Jean-François Perrier
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:STAR Protocols
Subjects:
Health Sciences
Genetics
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166724001199

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http://www.sciencedirect.com/science/article/pii/S2666166724001199

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