Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a comprehensive characterization of temporal changes in cel...

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Bibliographic Details
Main Authors: Lizhi He, Jhih-Hua Jhong, Qi Chen, Kai-Yao Huang, Karin Strittmatter, Johannes Kreuzer, Michael DeRan, Xu Wu, Tzong-Yi Lee, Nikolai Slavov, Wilhelm Haas, Alexander G. Marneros
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
macrophage polarization
M2-type polarization
M1-type polarization
MEK signaling
phosphoproteomics
retinoic acid signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721014327

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http://www.sciencedirect.com/science/article/pii/S2211124721014327

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