Genomic landscape of non‐small‐cell lung cancer with methylthioadenosine phosphorylase (MTAP) deficiency

Genomic landscape of non‐small‐cell lung cancer with methylthioadenosine phosphorylase (MTAP) deficiency

Abstract Introduction New treatment strategies for advanced non‐small‐cell lung carcinoma (NSCLC) include synthetic lethality targets focused on protein arginine methyl transferases such as PRMT5 that exploit the impact of genomic loss of methylthioadenosine phosphorylase (MTAP). Methods Twenty nine...

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Bibliographic Details
Main Authors: Prashanth Ashok Kumar, Stephen L. Graziano, Natalie Danziger, Dean Pavlick, Eric A. Severson, Shakti H. Ramkissoon, Richard S. P. Huang, Brennan Decker, Jeffrey S. Ross
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Cancer Medicine
Subjects:
comprehensive genomic profiling
methylthioadenosine phosphorylase (MTAP)
non‐small‐cell lung cancer
protein arginine methyl transferase
synthetic lethality
Online Access:https://doi.org/10.1002/cam4.4971

Internet

https://doi.org/10.1002/cam4.4971

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