Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway

Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway

Diabetes mellitus type 2 (T2DM) has been associated with alterations in the male reproductive tract, especially in the epididymis. Although it is known that T2DM alters epididymal physiology, disturbing mitochondrial function and favoring oxidative stress, the mechanisms remain unknown. Sirtuin 1 (S...

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Bibliographic Details
Main Authors: Antónia Diniz, Marco G. Alves, Emanuel Candeias, Ana I. Duarte, Paula I. Moreira, Branca M. Silva, Pedro F. Oliveira, Luís Rato
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
type 2 diabetes mellitus
male infertility
epididymis
mitochondrial function
oxidative parameters
Online Access:https://www.mdpi.com/1422-0067/23/16/8912

Internet

https://www.mdpi.com/1422-0067/23/16/8912

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