VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

Mechanistic understanding of antibiotic persistence is a prerequisite in controlling the emergence of MDR cases in Tuberculosis (TB). We have reported that the cholesterol-induced activation of VapC12 ribonuclease is critical for disease persistence in TB. In this study, we observed that relative to...

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Bibliographic Details
Main Authors: Shaifali Tyagi, Srikanth Sadhu, Taruna Sharma, Abhijit Paul, Manitosh Pandey, Vaibhav Kumar Nain, Deepak Kumar Rathore, Samrat Chatterjee, Amit Awasthi, Amit Kumar Pandey
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
toxin-antitoxin
virulence
neutrophils
persistence
and inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302163/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302163/full

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