The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program

The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program

GLUT9/SLC2A9 is a urate transporter and takes a fundamental role in the maintenance of normal serum urate levels. GLUT9 is the sole transporter of reabsorbed urate from renal epithelial cells to blood, thus making it an ideal pharmacological target for the development of urate-lowering drugs. None o...

Full description

Bibliographic Details
Main Authors: Antje Pommereau, Francesca Sassone, Alessandro Poli, Marcella De Silvestris, Lia Scarabottolo, Yasmin Zuschlag, Thomas Licher, Felix Bärenz
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:SLAS Discovery
Subjects:
Drug discovery
GLUT9
glucose transporter-9
urate transporter
high content screening
drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000558

Internet

http://www.sciencedirect.com/science/article/pii/S2472555224000558

Similar Items