Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or enzymatic transformations, to the active parent mole...

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Bibliographic Details
Main Authors: Rebecca Nofsinger, Sophie-Dorothee Clas, Rosa I. Sanchez, Abbas Walji, Kimberly Manser, Becky Nissley, Jaume Balsells, Amrithraj Nair, Qun Dang, David Jonathan Bennett, Michael Hafey, Junying Wang, John Higgins, Allen Templeton, Paul Coleman, Jay Grobler, Ronald Smith, Yunhui Wu
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Pharmaceuticals
Subjects:
prodrugs
colonic absorption
dog colonic studies
enabling QD dosing
chemistry-enabled drug delivery
enhancing lipophilicity
Online Access:http://www.mdpi.com/1424-8247/7/2/207

Internet

http://www.mdpi.com/1424-8247/7/2/207

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