Glycolytic regulation of cell rearrangement in angiogenesis

Glycolytic regulation of cell rearrangement in angiogenesis

Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this pre...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem, Anna Rita Cantelmo, Lena-Christin Conradi, Saar Vandekeere, Ann Bouché, Ivo Cornelissen, Stefan Vinckier, Roeland M. H. Merks, Elisabetta Dejana, Holger Gerhardt, Mieke Dewerchin, Katie Bentley, Peter Carmeliet
Format: Artikel
Sprache:English
Veröffentlicht: Nature Portfolio 2016-07-01
Schriftenreihe:Nature Communications
Online Zugang:https://doi.org/10.1038/ncomms12240

Online

https://doi.org/10.1038/ncomms12240

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