Glycolytic regulation of cell rearrangement in angiogenesis
Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this pre...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12240 |
| _version_ | 1818834949075107840 |
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| author | Bert Cruys Brian W. Wong Anna Kuchnio Dries Verdegem Anna Rita Cantelmo Lena-Christin Conradi Saar Vandekeere Ann Bouché Ivo Cornelissen Stefan Vinckier Roeland M. H. Merks Elisabetta Dejana Holger Gerhardt Mieke Dewerchin Katie Bentley Peter Carmeliet |
| author_facet | Bert Cruys Brian W. Wong Anna Kuchnio Dries Verdegem Anna Rita Cantelmo Lena-Christin Conradi Saar Vandekeere Ann Bouché Ivo Cornelissen Stefan Vinckier Roeland M. H. Merks Elisabetta Dejana Holger Gerhardt Mieke Dewerchin Katie Bentley Peter Carmeliet |
| author_sort | Bert Cruys |
| collection | DOAJ |
| description | Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction. |
| first_indexed | 2024-12-19T02:42:56Z |
| format | Article |
| id | doaj.art-f168b79c697d4569b921c383b7c0a3c0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:42:56Z |
| publishDate | 2016-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f168b79c697d4569b921c383b7c0a3c02022-12-21T20:39:05ZengNature PortfolioNature Communications2041-17232016-07-017111510.1038/ncomms12240Glycolytic regulation of cell rearrangement in angiogenesisBert Cruys0Brian W. Wong1Anna Kuchnio2Dries Verdegem3Anna Rita Cantelmo4Lena-Christin Conradi5Saar Vandekeere6Ann Bouché7Ivo Cornelissen8Stefan Vinckier9Roeland M. H. Merks10Elisabetta Dejana11Holger Gerhardt12Mieke Dewerchin13Katie Bentley14Peter Carmeliet15Department of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismLife Sciences Group, Centrum Wiskunde and InformaticaDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala UniversityDepartment of Oncology, Vascular Patterning LaboratoryDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala UniversityDepartment of Oncology, Laboratory of Angiogenesis and Vascular MetabolismGlycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.https://doi.org/10.1038/ncomms12240 |
| spellingShingle | Bert Cruys Brian W. Wong Anna Kuchnio Dries Verdegem Anna Rita Cantelmo Lena-Christin Conradi Saar Vandekeere Ann Bouché Ivo Cornelissen Stefan Vinckier Roeland M. H. Merks Elisabetta Dejana Holger Gerhardt Mieke Dewerchin Katie Bentley Peter Carmeliet Glycolytic regulation of cell rearrangement in angiogenesis Nature Communications |
| title | Glycolytic regulation of cell rearrangement in angiogenesis |
| title_full | Glycolytic regulation of cell rearrangement in angiogenesis |
| title_fullStr | Glycolytic regulation of cell rearrangement in angiogenesis |
| title_full_unstemmed | Glycolytic regulation of cell rearrangement in angiogenesis |
| title_short | Glycolytic regulation of cell rearrangement in angiogenesis |
| title_sort | glycolytic regulation of cell rearrangement in angiogenesis |
| url | https://doi.org/10.1038/ncomms12240 |
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